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A Potent Interdomain-Targeting Antibody Protects against SFTSV in Mice and Non-Human Primates

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分类
免疫学与微生物学
关键词
SFTSV; Neutralizing antibody; Interdomain epitope; Non-human primates

摘要

Severe fever with thrombocytopenia syndrome virus (SFTSV) poses a growing global health threat with substantial mortality and no effective treatments. We report the discovery of ZS1C5, a human antibody that neutralizes SFTSV with subnanomolar potency by targeting a previously unknown interdomain epitope on glycoprotein Gn, mediated by an elongated CDRH3. A single dose of ZS1C5 conferred robust protection in both murine and, for the first time, non-human primate SFTSV infection models, demonstrating rapid viral control and immune restoration. Importantly, we applied a structure-guided mining approach to human B cell repertoires and identified germline-encoded ZS1C5-like antibodies, underscoring the potential for rapid recall of protective immunity. Together, these findings establish ZS1C5 as a promising clinical candidate and provide a blueprint for developing therapeutics and vaccines targeting interdomain epitopes in emerging bunyaviruses.

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DOI：

https://doi.org/10.65215/apb7tn58

Submission ID：

34

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已发布

2025-11-28

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如何引用

Bi, J., Dai, Z., Hong, X., Meng, X., Yu, W., Sun, R., Liu, D., Wang, Z., Liu, H., Ma, Y., Yang, Y., Chen, Q., Song, G., Li, M., Li, X., Liu, Y., Wang, Q., Lu, S., Zhang, Y., … Li, D. (2025). A Potent Interdomain-Targeting Antibody Protects against SFTSV in Mice and Non-Human Primates. 浪淘沙预印本平台. https://doi.org/10.65215/apb7tn58

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