免疫学与微生物学
所有项目
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摘要:
Immunity against malignant cells and the ability of cancer cells to escape anticancer immunity constitute the core process of tumor development, but the underlying mechanism is still largely unknown. Through integrated analyses of clinical samples, cellular assays, and multiple murine tumor models, our study provides compelling evidence that mitochondrial RNA (mtRNA)-derived danger signals...
现已发表于 Vita. doi: 10.15302/vita.2026.01.0005 -
摘要:
Respiratory syncytial virus (RSV) poses a significant global health challenge, particularly affecting infants, the elderly, and immune compromised individuals. Despite recent progress in the development of vaccines and monoclonal antibodies, effective antiviral therapies remain limited. To advance the discovery of antiviral drugs, we have developed a dual-reporter RSV minigenome system, providing...
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摘要:
Antibody-dependent enhancement (ADE) of viral entry remains a mechanistically unresolved phenomenon in SARS-CoV-2 variants, with its variant-specificity and pathological consequences poorly defined. Through systematic profiling of 114 monoclonal antibodies (mAbs) across major variants of concern (VOCs), we discover that the Delta variant exhibits uniquely potent ADE mediated by mAbs targeting...
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摘要: Helicobacter pylori (H. pylori) infection is a major driver of gastric diseases, but with a global prevalence of nearly 50%, precise risk stratification among infected individuals remains challenging. Here, we constructed a comprehensive H. pylori proteome microarray encompassing 1,631 proteins and applied it to screen sera from patients with chronic atrophic gastritis (CAG), providing a...
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摘要:
Severe fever with thrombocytopenia syndrome virus (SFTSV) poses a growing global health threat with substantial mortality and no effective treatments. We report the discovery of ZS1C5, a human antibody that neutralizes SFTSV with subnanomolar potency by targeting a previously unknown interdomain epitope on glycoprotein Gn, mediated by an elongated CDRH3. A single dose of ZS1C5 conferred robust...
现已发表于 Vita. doi: 10.15302/vita.2025.12.0002 -
摘要:
Itaconate accumulates and manifests antibacterial activity in macrophages upon bacterial infection. Convincing evidence substantiates that itaconate transports across the plasma membrane and vacuolar membrane. But the molecular bases underlying the bidirectional transport of itaconate across membranes and how it affects intracellular bacterial replication remain elusive. Here, we identify MCT1...
现已发表于 Nature Communications. doi: 10.1038/s41467-025-65582-6