所有项目

• Helicobacter pylori Gpt targets SLC7A11 to trigger ferroptosis and promote chronic atrophic gastritis

  作者: Jingsen Yang，Jingjing Wei，Zheyao Hu，Min Liu，Chao Zheng，Hao Zhang，Yanjing Xiang，Qinkun Wang，Jiayi Shen，Jordi Marti，Zehao Zhuang，Xu Lin，Zhaowei Xu

  摘要:

  Helicobacter pylori (H. pylori) infection is...

  关键词: Helicobacter pylori; ferroptosis; chronic atrophic gastritis

  发布于: 首次发布 2025-12-18 | 最后更新 2025-12-18

  指标: 查看次数：161  |  下载次数：15  |  收藏次数：0

• A Potent Interdomain-Targeting Antibody Protects against SFTSV in Mice and Non-Human Primates

  作者: Jinhao Bi，Ziniu Dai，Xiaoci Hong，Yuanyuan Zhang，Shuaiyao Lu，Qiujing Wang，Yunshu Liu，Xinyi Li，Mingxi Li，Guangyuan Song，Qing Chen，Wenhai Yu，Yun Yang，Yingqiu Ma，Huasheng Liu，Xiangzhi Meng，Zhaoqian Wang，Dan Liu，Ren Sun，Qiangming Sun，Shibo Li，Qiang Zhou，Dapeng Li

  摘要:

  Severe fever with thrombocytopenia syndrome virus (SFTSV) poses a growing global health threat with substantial mortality and no effective treatments. We report the discovery of ZS1C5, a human antibody that neutralizes SFTSV with subnanomolar potency by targeting a previously unknown interdomain epitope on glycoprotein Gn, mediated by an elongated CDRH3....

  关键词: SFTSV; Neutralizing antibody; Interdomain epitope; Non-human primates

  发布于: 首次发布 2025-11-28 | 最后更新 2025-11-28

  指标: 查看次数：953  |  下载次数：570  |  收藏次数：1  |  版本：2

• Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity

  作者: Qingcai Meng，Chengxi Li，Yuping Cai，Ying Chen，Xiaoqing Chen，Xin Wang，Biling Zhang，Yue Zhang，Feng Liu，Meixin Chen

  摘要:

  Itaconate accumulates and manifests antibacterial activity in macrophages upon bacterial infection. Convincing evidence substantiates that itaconate transports across the plasma membrane and vacuolar membrane. But the molecular...

  关键词: bidirectional transport of itaconate; bacterial infection; macrophage

  发布于: 首次发布 2025-11-19 | 最后更新 2025-11-19

  指标: 查看次数：1660  |  下载次数：746  |  收藏次数：2