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• The assembly of osmoDroplet reveals dehydration sensing by helix transition and association

  作者: Jingjing Zhang，Panting Fan，Xuebo Quan，Yahui Zhao，Lefei Gao，Jingyi Zhang，Xiaofeng Fang，Kai Huang，Shengbo He

  摘要:

  Hyperosmotic stress triggers cellular dehydration and macromolecular crowding, leading to rapid biomolecular condensation. However, the individual roles of dehydration and crowding have been unclear, and the design principles of osmosensors remain poorly understood. Here, we identify a conserved sensor module comprising an osmo-sensing α-helix adjacent to an intrinsically disordered region (IDR)....

  关键词: Hyperosmotic stress; Dehydration sensing; OsmoDroplet; Biomolecular condensates; Phase separation

  发布于: 首次发布 2026-01-20

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