所有项目

• Raw Defines a Distinct TIR-fold cADPR Hydrolase Family and Cooperates with dSarm in Development and Axon Degeneration

  作者: Feng Chen，Zhuo Chen，Yongjun Tan，Xin Ye Shen，Matthew Leong，Jian Yuan Yang，Wan Hua Li，Yun Nan Hou，Guo Bao，Yue Jun Chen，Yu Ran Ma，Ting-Fung Chan，Hon Cheung Lee，Gyeong Hun Baeg，Dapeng Zhang，Yong Juan Zhao

  摘要:

  Conserved TIR domain proteins play essential roles in immune signaling, development, and neurodegeneration.

  关键词: Raw/OLRN-1; cADPR; NAD; SARM1/dSarm; TIR domain; axon degeneration; development; evolutionary analysis

  发布于: 首次发布 2025-12-19 | 最后更新 2025-12-19

  指标: 查看次数：273  |  下载次数：0  |  收藏次数：1

• Single-Cell Multi-omics Decodes the Aggrephagy Landscape, Unveiling TUBA4A as a Novel Oncogene and Immunotherapeutic Target in ccRCC

  作者: Kun Cui，Qiuxin Duan，Zhe Xu，Wenjing Liu，Yueli Ni，Yongping Li，Lu Yuan，Zhuoran Teng，Yurong Dong，Ziyuan Bai，Asif Shahzad，Jianshan Zhang，Yu Dou，Jiaojiao Xia，Hanyue Shao，Zhe Yang，Qiao Zhang

  摘要:

  Clear cell renal cell carcinoma (ccRCC) is an aggressive malignancy with a complex and immunosuppressive tumor microenvironment (TME). While aggrephagy, a selective autophagy process, has been linked to cancer, its role in ccRCC remains unclear. Through integrated multi-omics analysis of single-cell and bulk sequencing data, we constructed the first aggrephagy activity atlas in ccRCC TME,...

  关键词: ccRCC; aggrephagy; tumor microenvironment; prognosis

  发布于: 首次发布 2025-11-18 | 最后更新 2025-11-18

  指标: 查看次数：573  |  下载次数：344  |  收藏次数：2