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• Nuclear envelope tethering of the genome modulates cohesin loop extrusion

  Authors: Fengnian Shan, Han Zhao, Shiyi Qin, En Lin, Sijian Xia, Yinzhi Lin, Fangxuan Lyu, Chongren Pei, Fuhai Liu, Qiao Guo, Siyu Li, Lirong Shu, Manzhu Wang, Yongjia Weng, Bicheng Li, Kai Huang, Haoyue Zhang

  Abstract:

  The nuclear envelope (NE) plays a crucial role in genome organization by tethering heterochromatin to the nuclear periphery. Yet, how individual NE-associating factors regulate 3D genome architecture remains incompletely understood. Here, we leverage the mitosis-to-G1 phase transition as an experimental system to dissect the roles of Lamin A/C and Lamin B receptor (LBR) in post-mitotic genome...

  Keywords: Cohesin; loop extrusion; nuclear envelope; chromatin structure; LBR

  Timeline: First Posted 2026-01-30 | Last Updated 2026-01-31

  Metrics: Views: 409  |  Downloads: 45  |  Favorites: 0  |  Versions: 2

• Raw Defines a Distinct TIR-fold cADPR Hydrolase Family and Cooperates with dSarm in Development and Axon Degeneration

  Authors: Feng Chen, Zhuo Chen, Yongjun Tan, Xin Ye Shen, Matthew Leong, Jian Yuan Yang, Wan Hua Li, Yun Nan Hou, Guo Bao, Yue Jun Chen, Yu Ran Ma, Ting-Fung Chan, Hon Cheung Lee, Gyeong Hun Baeg, Dapeng Zhang, Yong Juan Zhao

  Abstract: Conserved TIR domain proteins play essential roles in immune signaling, development, and neurodegeneration. Here, we identify Raw as a member of a distinct TIR protein family that functions as a cADPR-specific hydrolase, with catalytic mutations phenocopying delayed axon degeneration. While Raw and dSarm synergistically deplete NAD to drive axon degeneration, they antagonistically regulate cADPR...

  Keywords: Raw/OLRN-1; cADPR; NAD; SARM1/dSarm; TIR domain; axon degeneration; development; evolutionary analysis

  Timeline: First Posted 2025-12-19

  Metrics: Views: 1038  |  Downloads: 432  |  Favorites: 1

• Single-Cell Multi-omics Decodes the Aggrephagy Landscape, Unveiling TUBA4A as a Novel Oncogene and Immunotherapeutic Target in ccRCC

  Authors: Kun Cui, Qiuxin Duan, Zhe Xu, Wenjing Liu, Yueli Ni, Yongping Li, Lu Yuan, Zhuoran Teng, Yurong Dong, Ziyuan Bai, Asif Shahzad, Jianshan Zhang, Yu Dou, Jiaojiao Xia, Hanyue Shao, Zhe Yang, Qiao Zhang

  Abstract:

  Clear cell renal cell carcinoma (ccRCC) is an aggressive malignancy with a complex and immunosuppressive tumor microenvironment (TME). While aggrephagy, a selective autophagy process, has been linked to cancer, its role in ccRCC remains unclear. Through integrated multi-omics analysis of single-cell and bulk sequencing data, we constructed the first aggrephagy activity atlas in ccRCC TME,...

  Keywords: ccRCC; aggrephagy; tumor microenvironment; prognosis

  Timeline: First Posted 2025-11-18

  Metrics: Views: 793  |  Downloads: 211  |  Favorites: 2