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• A Sphingomyelin-Sensing Pathway Governing Metabolic Inflammation

  Authors: Jianfei Zheng, Chunling Xu, Zhuo Wang, Tao Yao, Haodong Wang, Xubo Lin, Kangling Zhu, Yurong Liu, Dong Peng, Fengwu Chen, Zhewen Qin, Min Zhang, Bo Shan, Liang Ge

  Abstract:

  Obesity-associated metabolic inflammation is driven by lipid-laden macrophages that release proinflammatory cytokines such as interleukin-1β, yet how macrophages sense lipid overload to trigger inflammation remains unclear. Here, we identify sphingomyelin sensing as a key mechanism linking lipid metabolism to inflammatory activation. We show that macrophages detect specific sphingomyelin species...

  Keywords: metabolic inflammation; sphingomyelin; interleukin-1β; obesity; adipose tissue macrophages; lipid sensor; TMED10; translocation; unconventional secretion

  Timeline: First Posted 2026-01-19

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