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• A Sphingomyelin-Sensing Pathway Governing Metabolic Inflammation

  作者: Jianfei Zheng，Chunling Xu，Zhuo Wang，Tao Yao，Haodong Wang，Xubo Lin，Kangling Zhu，Yurong Liu，Dong Peng，Fengwu Chen，Zhewen Qin，Min Zhang，Bo Shan，Liang Ge

  摘要:

  Obesity-associated metabolic inflammation is driven by lipid-laden macrophages that release proinflammatory cytokines such as interleukin-1β, yet how macrophages sense lipid overload to trigger inflammation remains unclear. Here, we identify sphingomyelin sensing as a key mechanism linking lipid metabolism to inflammatory activation. We show that macrophages detect specific sphingomyelin species...

  关键词: metabolic inflammation; sphingomyelin; interleukin-1β; obesity; adipose tissue macrophages; lipid sensor; TMED10; translocation; unconventional secretion

  发布于: 首次发布 2026-01-19

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