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• Alternative tandem transcription initiation links noncoding variants to human disease through translational control

  Authors: Xudong Zou, Wei Wang, Xing Li, Yinuo Wang, Hui Chen, Shuxin Chen, Feihong Weng, Qin Li, Chen Yu, Lei Li

  Abstract:

  Alternative tandem transcription initiation (ATI) is a pervasive mechanism of gene regulation, yet its genetic impact on human disease remains largely unknown. Here, we systematically quantified genetic regulation of ATI across 25,859 samples from 49 human normal tissues and 33 tumor tissues. We identified ~0.4 million 5′ UTR ATI quantitative trait loci (5′aQTLs) in 5,295 genes, with 32%...

  Keywords: Alternative transcription initiation; translational regulation; cancer risk

  Timeline: First Posted 2025-11-19 | Last Updated 2025-11-19

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