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• Helicobacter pylori Gpt targets SLC7A11 to trigger ferroptosis and promote chronic atrophic gastritis

  Authors: Jingsen Yang, Jingjing Wei, Zheyao Hu, Min Liu, Chao Zheng, Hao Zhang, Yanjing Xiang, Qinkun Wang, Jiayi Shen, Jordi Marti, Zehao Zhuang, Xu Lin, Zhaowei Xu

  Abstract:

  Helicobacter pylori (H. pylori) infection is...

  Keywords: Helicobacter pylori; ferroptosis; chronic atrophic gastritis

  Timeline: First Posted 2025-12-18 | Last Updated 2025-12-18

  Metrics: Views: 156  |  Downloads: 15  |  Favorites: 0

• A Potent Interdomain-Targeting Antibody Protects against SFTSV in Mice and Non-Human Primates

  Authors: Jinhao Bi, Ziniu Dai, Xiaoci Hong, Yuanyuan Zhang, Shuaiyao Lu, Qiujing Wang, Yunshu Liu, Xinyi Li, Mingxi Li, Guangyuan Song, Qing Chen, Wenhai Yu, Yun Yang, Yingqiu Ma, Huasheng Liu, Xiangzhi Meng, Zhaoqian Wang, Dan Liu, Ren Sun, Qiangming Sun, Shibo Li, Qiang Zhou, Dapeng Li

  Abstract:

  Severe fever with thrombocytopenia syndrome virus (SFTSV) poses a growing global health threat with substantial mortality and no effective treatments. We report the discovery of ZS1C5, a human antibody that neutralizes SFTSV with subnanomolar potency by targeting a previously unknown interdomain epitope on glycoprotein Gn, mediated by an elongated CDRH3....

  Keywords: SFTSV; Neutralizing antibody; Interdomain epitope; Non-human primates

  Timeline: First Posted 2025-11-28 | Last Updated 2025-11-28

  Metrics: Views: 951  |  Downloads: 570  |  Favorites: 1  |  Versions: 2

• Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity

  Authors: Qingcai Meng, Chengxi Li, Yuping Cai, Ying Chen, Xiaoqing Chen, Xin Wang, Biling Zhang, Yue Zhang, Feng Liu, Meixin Chen

  Abstract:

  Itaconate accumulates and manifests antibacterial activity in macrophages upon bacterial infection. Convincing evidence substantiates that itaconate transports across the plasma membrane and vacuolar membrane. But the molecular...

  Keywords: bidirectional transport of itaconate; bacterial infection; macrophage

  Timeline: First Posted 2025-11-19 | Last Updated 2025-11-19

  Metrics: Views: 1659  |  Downloads: 746  |  Favorites: 2