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• PNPT1-mtRNA axis mediates chemotherapy-induced immune signaling and can be targeted to overcome therapeutic resistance

  Authors: Mingfu Tian, Siyu Liu, Xu Li, Zelin Chai, Zhiqiang Li, Hong Fan, Chengliang Zhu, Kailang Wu, Ke Lan

  Abstract:

  Immunity against malignant cells and the ability of cancer cells to escape anticancer immunity constitute the core process of tumor development, but the underlying mechanism is still largely unknown. Through integrated analyses of clinical samples, cellular assays, and multiple murine tumor models, our study provides compelling evidence that mitochondrial RNA (mtRNA)-derived danger signals...

  Keywords: chemotherapy; antitumor immunity; mt dsRNA; MAVS; PNPT1; cancer immunotherapy

  Timeline: First Posted 2026-01-20

  Metrics: Views: 504  |  Downloads: 280  |  Favorites: 2

  Now published in Vita. doi: 10.15302/vita.2026.01.0005

• Establishment of a Dual-Reporter Minigenome System for Respiratory Syncytial Virus

  Authors: Li Pan, Yunbo Xu, Yihan Ma, Jiaxing Zhang, Chao Wu

  Abstract:

  Respiratory syncytial virus (RSV) poses a significant global health challenge, particularly affecting infants, the elderly, and immune compromised individuals. Despite recent progress in the development of vaccines and monoclonal antibodies, effective antiviral therapies remain limited. To advance the discovery of antiviral drugs, we have developed a dual-reporter RSV minigenome system, providing...

  Keywords: Respiratory Syncytial Virus; Minigenome; Antiviral

  Timeline: First Posted 2026-01-17

  Metrics: Views: 551  |  Downloads: 41  |  Favorites: 2

• Divergent antibody-enhanced entry across SARS-CoV-2 lineages drives variant-specific immunopathology through epistatically constrained spike evolution​​

  Authors: Yuru Han, Song Xue, Wei Xu, Yuanzhe Zhang, Xiaofang Peng, Yunjiao Zhou, Fei Wu, Minxiang Xie, Wei Wu, Anqi Xia, Yidan Gao, Jianbo Wu, Zezhong Liu, Jingsong Zhang, Shibo Jiang, Zhixiang Zuo, Fan Wu, Qiao Wang

  Abstract:

  Antibody-dependent enhancement (ADE) of viral entry remains a mechanistically unresolved phenomenon in SARS-CoV-2 variants, with its variant-specificity and pathological consequences poorly defined. Through systematic profiling of 114 monoclonal antibodies (mAbs) across major variants of concern (VOCs), we discover that the Delta variant exhibits uniquely potent ADE mediated by mAbs targeting...

  Keywords: SARS-CoV-2; ADE; antibody; variant

  Timeline: First Posted 2025-12-22

  Metrics: Views: 508  |  Downloads: 124  |  Favorites: 1

• Helicobacter pylori Gpt targets SLC7A11 to trigger ferroptosis and promote chronic atrophic gastritis

  Authors: Jingsen Yang, Jingjing Wei, Zheyao Hu, Min Liu, Chao Zheng, Hao Zhang, Yanjing Xiang, Qinkun Wang, Jiayi Shen, Jordi Marti, Zehao Zhuang, Xu Lin, Zhaowei Xu

  Abstract: Helicobacter pylori (H. pylori) infection is a major driver of gastric diseases, but with a global prevalence of nearly 50%, precise risk stratification among infected individuals remains challenging. Here, we constructed a comprehensive H. pylori proteome microarray encompassing 1,631 proteins and applied it to screen sera from patients with chronic atrophic gastritis (CAG), providing a...

  Keywords: Helicobacter pylori; ferroptosis; chronic atrophic gastritis

  Timeline: First Posted 2025-12-18

  Metrics: Views: 485  |  Downloads: 131  |  Favorites: 1

• A Potent Interdomain-Targeting Antibody Protects against SFTSV in Mice and Non-Human Primates

  Authors: Jinhao Bi, Ziniu Dai, Xiaoci Hong, Yuanyuan Zhang, Shuaiyao Lu, Qiujing Wang, Yunshu Liu, Xinyi Li, Mingxi Li, Guangyuan Song, Qing Chen, Wenhai Yu, Yun Yang, Yingqiu Ma, Huasheng Liu, Xiangzhi Meng, Zhaoqian Wang, Dan Liu, Ren Sun, Qiangming Sun, Shibo Li, Qiang Zhou, Dapeng Li

  Abstract:

  Severe fever with thrombocytopenia syndrome virus (SFTSV) poses a growing global health threat with substantial mortality and no effective treatments. We report the discovery of ZS1C5, a human antibody that neutralizes SFTSV with subnanomolar potency by targeting a previously unknown interdomain epitope on glycoprotein Gn, mediated by an elongated CDRH3. A single dose of ZS1C5 conferred robust...

  Keywords: SFTSV; Neutralizing antibody; Interdomain epitope; Non-human primates

  Timeline: First Posted 2025-11-28 | Last Updated 2025-11-28

  Metrics: Views: 1818  |  Downloads: 755  |  Favorites: 1  |  Versions: 2

  Now published in Vita. doi: 10.15302/vita.2025.12.0002

• Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity

  Authors: Qingcai Meng, Chengxi Li, Yuping Cai, Ying Chen, Xiaoqing Chen, Xin Wang, Biling Zhang, Yue Zhang, Feng Liu, Meixin Chen

  Abstract:

  Itaconate accumulates and manifests antibacterial activity in macrophages upon bacterial infection. Convincing evidence substantiates that itaconate transports across the plasma membrane and vacuolar membrane. But the molecular bases underlying the bidirectional transport of itaconate across membranes and how it affects intracellular bacterial replication remain elusive. Here, we identify MCT1...

  Keywords: bidirectional transport of itaconate; bacterial infection; macrophage

  Timeline: First Posted 2025-11-19

  Metrics: Views: 2236  |  Downloads: 321  |  Favorites: 2

  Now published in Nature Communications. doi: 10.1038/s41467-025-65582-6