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• Genetic-Morphological Synergy Governs Cell Fate Specification in Development

  Authors: Guoye Guan, Yixuan Chen, Hongli Wang

  Abstract:

  Cell morphology reflects cellular states, particularly cell fates with specific spatiotemporal features, like the spreading of epidermal cells in skin. However, how cell morphology relates to cell fate and genetic programs remains unclear. In this study, we leveraged the up-to-date lineage-resolved 3D cell morphology dataset of worm Caenorhabditis elegans embryogenesis. Twelve quantitative...

  Keywords: cell morphology; gene expression; cell fate differentiation; coupling and decoupling; metazoan development; germ layer; tissue and organ; body axis; Caenorhabditis elegans embryogenesis

  Timeline: First Posted 2025-12-16

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