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• Raw Defines a Distinct TIR-fold cADPR Hydrolase Family and Cooperates with dSarm in Development and Axon Degeneration

  Authors: Feng Chen, Zhuo Chen, Yongjun Tan, Xin Ye Shen, Matthew Leong, Jian Yuan Yang, Wan Hua Li, Yun Nan Hou, Guo Bao, Yue Jun Chen, Yu Ran Ma, Ting-Fung Chan, Hon Cheung Lee, Gyeong Hun Baeg, Dapeng Zhang, Yong Juan Zhao

  Abstract:

  Conserved TIR domain proteins play essential roles in immune signaling, development, and neurodegeneration.

  Keywords: Raw/OLRN-1; cADPR; NAD; SARM1/dSarm; TIR domain; axon degeneration; development; evolutionary analysis

  Timeline: First Posted 2025-12-19 | Last Updated 2025-12-19

  Metrics: Views: 260  |  Downloads: 0  |  Favorites: 1

• Single-Cell Multi-omics Decodes the Aggrephagy Landscape, Unveiling TUBA4A as a Novel Oncogene and Immunotherapeutic Target in ccRCC

  Authors: Kun Cui, Qiuxin Duan, Zhe Xu, Wenjing Liu, Yueli Ni, Yongping Li, Lu Yuan, Zhuoran Teng, Yurong Dong, Ziyuan Bai, Asif Shahzad, Jianshan Zhang, Yu Dou, Jiaojiao Xia, Hanyue Shao, Zhe Yang, Qiao Zhang

  Abstract:

  Clear cell renal cell carcinoma (ccRCC) is an aggressive malignancy with a complex and immunosuppressive tumor microenvironment (TME). While aggrephagy, a selective autophagy process, has been linked to cancer, its role in ccRCC remains unclear. Through integrated multi-omics analysis of single-cell and bulk sequencing data, we constructed the first aggrephagy activity atlas in ccRCC TME,...

  Keywords: ccRCC; aggrephagy; tumor microenvironment; prognosis

  Timeline: First Posted 2025-11-18 | Last Updated 2025-11-18

  Metrics: Views: 572  |  Downloads: 344  |  Favorites: 2