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• The assembly of osmoDroplet reveals dehydration sensing by helix transition and association

  Authors: Jingjing Zhang, Panting Fan, Xuebo Quan, Yahui Zhao, Lefei Gao, Jingyi Zhang, Xiaofeng Fang, Kai Huang, Shengbo He

  Abstract:

  Hyperosmotic stress triggers cellular dehydration and macromolecular crowding, leading to rapid biomolecular condensation. However, the individual roles of dehydration and crowding have been unclear, and the design principles of osmosensors remain poorly understood. Here, we identify a conserved sensor module comprising an osmo-sensing α-helix adjacent to an intrinsically disordered region (IDR)....

  Keywords: Hyperosmotic stress; Dehydration sensing; OsmoDroplet; Biomolecular condensates; Phase separation

  Timeline: First Posted 2026-01-20

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