所有项目

• Nuclear envelope tethering of the genome modulates cohesin loop extrusion

  作者: Fengnian Shan，Han Zhao，Shiyi Qin，En Lin，Sijian Xia，Yinzhi Lin，Fangxuan Lyu，Chongren Pei，Fuhai Liu，Qiao Guo，Siyu Li，Lirong Shu，Manzhu Wang，Yongjia Weng，Bicheng Li，Kai Huang，Haoyue Zhang

  摘要:

  The nuclear envelope (NE) plays a crucial role in genome organization by tethering heterochromatin to the nuclear periphery. Yet, how individual NE-associating factors regulate 3D genome architecture remains incompletely understood. Here, we leverage the mitosis-to-G1 phase transition as an experimental system to dissect the roles of Lamin A/C and Lamin B receptor (LBR) in post-mitotic genome...

  关键词: Cohesin; loop extrusion; nuclear envelope; chromatin structure; LBR

  发布于: 首次发布 2026-01-30 | 最后更新 2026-01-31

  指标: 查看次数：418  |  下载次数：45  |  收藏次数：0  |  版本：2

• Raw Defines a Distinct TIR-fold cADPR Hydrolase Family and Cooperates with dSarm in Development and Axon Degeneration

  作者: Feng Chen，Zhuo Chen，Yongjun Tan，Xin Ye Shen，Matthew Leong，Jian Yuan Yang，Wan Hua Li，Yun Nan Hou，Guo Bao，Yue Jun Chen，Yu Ran Ma，Ting-Fung Chan，Hon Cheung Lee，Gyeong Hun Baeg，Dapeng Zhang，Yong Juan Zhao

  摘要: Conserved TIR domain proteins play essential roles in immune signaling, development, and neurodegeneration. Here, we identify Raw as a member of a distinct TIR protein family that functions as a cADPR-specific hydrolase, with catalytic mutations phenocopying delayed axon degeneration. While Raw and dSarm synergistically deplete NAD to drive axon degeneration, they antagonistically regulate cADPR...

  关键词: Raw/OLRN-1; cADPR; NAD; SARM1/dSarm; TIR domain; axon degeneration; development; evolutionary analysis

  发布于: 首次发布 2025-12-19

  指标: 查看次数：1042  |  下载次数：432  |  收藏次数：1

• Single-Cell Multi-omics Decodes the Aggrephagy Landscape, Unveiling TUBA4A as a Novel Oncogene and Immunotherapeutic Target in ccRCC

  作者: Kun Cui，Qiuxin Duan，Zhe Xu，Wenjing Liu，Yueli Ni，Yongping Li，Lu Yuan，Zhuoran Teng，Yurong Dong，Ziyuan Bai，Asif Shahzad，Jianshan Zhang，Yu Dou，Jiaojiao Xia，Hanyue Shao，Zhe Yang，Qiao Zhang

  摘要:

  Clear cell renal cell carcinoma (ccRCC) is an aggressive malignancy with a complex and immunosuppressive tumor microenvironment (TME). While aggrephagy, a selective autophagy process, has been linked to cancer, its role in ccRCC remains unclear. Through integrated multi-omics analysis of single-cell and bulk sequencing data, we constructed the first aggrephagy activity atlas in ccRCC TME,...

  关键词: ccRCC; aggrephagy; tumor microenvironment; prognosis

  发布于: 首次发布 2025-11-18

  指标: 查看次数：797  |  下载次数：211  |  收藏次数：2