计算生物学与生物信息学
所有项目
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A continuous cost–efficiency spectrum governs brain-wide communication and cognitive reconfiguration
摘要:Information communication in the brain must balance efficient functional integration with the metabolic and physical costs of long-range connectivity. How this cost–efficiency balance is implemented in large-scale communication networks, and how it adapts across cognitive states and pathology, remains poorly understood. In this study, by systematically tuning the strength of distance constraints...
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摘要:
Tokenization is a critical design choice in genomic language modeling. Widely used schemes---character-level encoding, fixed-length $k$-mers, and greedy subword algorithms such as BPE---show intrinsic limitations on DNA that are magnified by the small four-letter alphabet. To address this, we adapt Ladderpath, an Algorithmic Information Theory method that identifies nested and hierarchical...
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摘要: Background. Positron Emission Tomography (PET) is a vital medical imaging tool for studying in vivo metabolism. However, conventional PET systems are limited in their inability to image during free movement. Therefore, we have developed a wearable brain PET system for real-time imaging, called SmartBrain. Methods. The SmartBrain used 192 detectors and the detector consists of a 6 × 6...