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• A De Novo Gain-of-Function Variant of DNM1L Causes Developmental Encephalopathy

  Authors: Shangsheng Dong, Yanjuan Chen, Mengfang Yan, Xiaoli Huang, Qiannan Deng, Jianxiang Liao, Ke Zhang

  Abstract:

  Background: Variants in the dynamin 1-like (DNM1L) gene, which encodes...

  Keywords: neurodevelopmental disorders; DNM1L; mitochondria; protein aggregate

  Timeline: First Posted 2025-11-26 | Last Updated 2025-11-26

  Metrics: Views: 472  |  Downloads: 268  |  Favorites: 0

• Intercellular DNA transfer mediated by migrasomes propagates genome instability

  Authors: Yi Li, Yihan Tang, Guojun Ye, Chunzhuo Liu, Yide He, Chunyu Song, Weiping Chang, Yuwei Huang, Wei-ke Ji, Lin Deng

  Abstract:

  Genome instability drives tumor evolution through incremental mutations and catastrophic events such as chromothripsis. Despite significant advances, the...

  Keywords: Genomic instability; Chromosome bridge; Migrasome; Chromocytosis; Intercellular DNA transfer

  Timeline: First Posted 2025-11-20 | Last Updated 2025-11-20

  Metrics: Views: 2067  |  Downloads: 604  |  Favorites: 4

• A Mechano-Feedback Loop Orchestrated by SUN1/2 Governs Cellular Mechanoadaptation via Lamina-Associated Domain Remodeling

  Authors: Yafan Xie, Zhaoyan Zuo, Yanjing Zhao, Liping Guo, Wei Xu, Juhui Qiu, Guixue Wang, Qin Peng

  Abstract:

  SUN1/2, core components of the linker of nucleoskeleton and cytoskeleton (LINC) complex, transmit extracellular mechanical forces to nuclear lamina and chromatin. However, their role in regulating peripheral chromatin in mechanosensing and mechanoadaptation remains unclear. Using CRISPR/Cas9-mediated knockout of Sun1 or Sun2 in...

  Keywords: Mechano-feedback loop; SUN1/2; Mechanoadaptation; LADs

  Timeline: First Posted 2025-11-19 | Last Updated 2025-11-19

  Metrics: Views: 462  |  Downloads: 259  |  Favorites: 3

• Matrix Stiffness Induces Midnolin-dependent Lamin B1 Degradation to Control Myoblast Differentiation

  Authors: Liping Guo, Yanjing Zhao, Zhe Zhang, Chang Sun, Yafan Xie, Qin Dai, Yan Yan, Yaoqi Zhou, Yang Zhang, Quhuan Li, Juhui Qiu, Qin Peng

  Abstract:

  Cells decode mechanical cues to direct fate decisions through nuclear remodeling, yet nuclear adaptors to mechanical signals remain elusive. Here, we show that soft matrix suppresses myoblast differentiation and induces nuclear abnormality within 30 minutes, accompanied by a >60% reduction in lamin B1 proteins levels. Mechanistically, midnolin...

  Keywords: Matrix stiffness; Lamin B1 degradation; midnolin-proteasome pathway; myoblast differentiation

  Timeline: First Posted 2025-11-19 | Last Updated 2025-11-19

  Metrics: Views: 496  |  Downloads: 312  |  Favorites: 3