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• A Pooled Neuronal Activity Screen Links TMEM50A-Dependent MVB Function to Synaptic Integrity and Remote Memory

  作者: Jianhui Wang，Meiqi Liu，Yiming Chen，Jiancheng Chen，Xin Zhong，Zilong Wang，Xian Jiang，Ruilin Tian

  摘要:

  While advances in omics profiling have rapidly expanded the catalog of genes associated with brain activity in health and disease, functional annotation has lagged far behind. Here, we establish a high-throughput functional genomics platform that couples the calcium-integrating sensor CaMPARI2 with CRISPRi screening in human iPSC-derived neurons. By converting cumulative neuronal activity into a...

  发布于: 首次发布 2026-01-22 | 最后更新 2026-01-22

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