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• A Pooled Neuronal Activity Screen Links TMEM50A-Dependent MVB Function to Synaptic Integrity and Remote Memory

  Authors: Jianhui Wang, Meiqi Liu, Yiming Chen, Jiancheng Chen, Xin Zhong, Zilong Wang, Xian Jiang, Ruilin Tian

  Abstract:

  While advances in omics profiling have rapidly expanded the catalog of genes associated with brain activity in health and disease, functional annotation has lagged far behind. Here, we establish a high-throughput functional genomics platform that couples the calcium-integrating sensor CaMPARI2 with CRISPRi screening in human iPSC-derived neurons. By converting cumulative neuronal activity into a...

  Timeline: First Posted 2026-01-22 | Last Updated 2026-01-22

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